Bregma Ayurvedic Brain Health Tonic For Children and Adult

Product Profile

Each 10 ml contains extract of

Jatamansi	100mg	Giloy	100mg
Tagar	100mg	Mulethi	100mg
Sarpagandha	50mg	Trikatu	100mg
Shankhapushpi	200mg	Tulsi	200mg
Brahmi	200mg	Ushira	100mg
Ashwagandha	500mg	Nishoth	50mg
Draksha	100mg	Dalchini	25mg
Triphala	100mg	Gajar	25mg
Vacha	200mg	Haldi	20mg
Malkangni	100mg	Kharbooja seed	50mg
Shatavari	200mg	Giloy	100mg

Jatamansi (Nardostachys Jatamansi)
Jatamansi is a reputed ayurvedic herb and used in various multiple formulations. It has several activities including anticonvulsant, anti-parkinson’s, tranquilizing, hepatoprotective, neuroprotective, hypotensive, anti-diabetic activity. It is described as medhya (brain tonic), rasayna (rejuvenative to the mind), nidrajnana (promotes sleep), manasrogaghana (alleviates mental diseases) in ayurveda. It is primarily used in modern medicine for cognitive and neurological function benefits. It is used in mental disorder, insomnia, hypertension and heart diseases. It is very effective in producing typical non-specific stress manifestation. (Journal of Pharmacognosy & Phytochemistry 2015; 3(5) ; 102-106)

Clinical studies suggest that n. Jatamansi has dose dependent anti-depressant activity and can be used in patients suffering from depression due to sleep disturbances. Ethanolic extract of jatamansi significantly improved learning and memory and hence can be used as a memory restorative agent in the treatment of dementia seen in elderly persons. It possesses significant anti-stress activity which may be due to its antioxidant activity. (Orient. J. Chem. ; vol.32(2), 859-866)

Tagar (Valeriana Wallichii)
Tagar is a well known indian traditional medicinal herb with sleep remedy. It is used for the treatment of varied nervous disorders. It is used as a nervine sedative in nervous anxiety. Valerian root has been used for a centuary as a relaxing and sleep promoting plant. It is also used to treat hysteria, hypochondriasis, nervous unrest and similar emotional states. The root has been medically used to treat insomnia and mental disorders. It is used as sedative, anxiolytic and anti-depressant. (Asian Journal of Pharmaceutical & Clinical Research, vol. 11, issue 1, 2018)

Wallichii have potential anxiolytic activity. It showed a beneficial effect on learning and memory impairment in clinical studies. Aqueous extract of v. Wallichii has quantifying effects of mild sedatives on both physiological and subjective aspects of sleep. The essential oil of v. Wallichii exerted anti-depressant activity. (World Journal of Pharmacy & Pharmaceutical Sciences, vol.3, issue 9, 2014)

Sarpagandha (Rauwolfia Serpentina)
Serpentina is an important medicinal plant due to the presence of its immense therapeutic properties. It is used in ayurvedic medicine for curing high blood pressure, mental agitation, epilepsy, traumas, anxiety, excitement, schizophrenia, insomnia and insanity. Reserpine is the principle alkaloid which shows large number of clinical applications. It is useful in the treatment of hypertension, cardiovascular diseases and neurological diseases. It is used mainly as a natural tranquilizer. It helps in sedation and lowering of blood pressure, especially in cases of hypertension exacerbated by stress and sympathetic nervous system activity. (International Journal of Pharmaceutical Sciences Review & Research, 23(2), Nov-Dec 2013, 348-355)

Shankhpushpi (Convolvulus Pluricaulis)                       
Shankhpushpi is known as best brain tonic medicine which is classified under four medhya rasayana (brain tonic) by acharya charaka. It is also included as main ingredient in many herbal interactive or decoction based brain tonics or memory boosting formulations. It may have protruding action on central nervous system where it helps to improve grasping power, memory, intellectual behavior, speech and mood personality disorders of an individual. Various researchers claimed that it acts as molecular nutrient for brain activities to relieve mental fatigue, anxiety, stress etc. It possess memory enhancing, anxiolytic and cns-depressant activity. The dried powder of shankhpushpi showed significant anxiolytic behavior. The aqueous extract of roots also showed the neuroprotective properties by scavenging various reactive oxygen species. The ethanolic extract of plant showed the significant result in nerve growth factor, which could be the reason of boosting in cognition power. In indian tradition, shankhpushpi is a well trusted natural remedy for memory improvement in children. (Journal of Ayurvedic & Herbal Medicine 2021)

Brahmi (Bacopa Monnieri)
Monnieri is classified as medhya rasayana in ayurvedic text of charaka. Charaka described the efficacy of bacopa in treating old age and age related diseases, promoting memory and intellect, increasing the life span, providing nourishment and improving clarity of voice, complexion and luster. The active compounds in b. Monnieri, known as bacosides, are shown to positively influence brain cells that prompt the regeneration of brain tissue. Brahmi works to improve cognitive function in people of all ages. This herb also helps to improve mood. Bacopa is a very good natural antioxidant which shows neuroprotective properties in the memory centers of the brain and cell protective effects. The preliminary clinical studies have shown improvement of cognitive function in humans. It has been found to be very beneficial in treatment of anxiety neurosis and mental fatigue. It has been found to significantly improve iq levels, general ability, behavioral patterns and mental concentration in children. B. Monnieri is useful for improving mental clarity, confidence and memory recall. Bacopa also increases level of serotonin, a brain chemical known to promote relaxation. The herb’s ability to boost brain function while reducing anxiety may explain why it helps treat adhd. It also induces a sense of calm and peace. It helps soothe the restlessness and distraction that nervousness causes. (Indian Journal of Agriculture & Allied Sciences, vol.2, no. 3, 2016)

Ashwagandha (Withania Somnifera)
Ashwagandha is a very revered herb of the indian ayurvedic system of medicine as a rasayana (tonic). It is used for various kinds of disease processes and specially as a nervine tonic. Being a powerful adaptogen, it enhances the body’s resilience to stress. Clinical studies indicate that it is a potent antistress agent. Ashwagandha is used to promote intellect and memory. It has a cognition promoting effect and is useful in children with memory deficit and in age related loss of memory. It was also found useful in neurodegenerative diseases. Clinical studies support the use of ashwagandha as a mood stabilizer in clinical conditions of anxiety and depression. (African Journal of Traditional, Complementary & Alternative Medicine, 2011)

Vacha (Acorus Calamus)
Vacha roots and rhizome have been used in indian system of traditional medicine for hundreds of years and it is highly valued as a rejuvenator for the brain and nervous system. A. Calamus rhizome constituents, particularly α and β- asarone, possess a wide range of pharmacological activities such as sedative, cns depressant, behavior modifying, anti-convulsant and memory enhancing. Administration of vacha in cases of depression showed reduction in the degree of severity of depression and better rehabilitation and also a significant improvement in symptoms. Α and β-asarone showed many parmacodynamic actions similar to some well established tranquilizers. Vacha is regarded as rasayana in ayurvedic medicine and has been used to treat memory loss and other mental disorders. (Journal of Scientific & Innovative Research 2013; 2(5) : 950-954)

Malkangni (Celastrus Paniculatus)
Paniculatus is used to treat brain related disorders and to enhance learning and memory. The jyotishmati oil extracted from the seeds of malkangni is known to have effect on central nervous system. C. Paniculatus may be employed as stimulant, nerve tonic, rejuvenant, sedative and tranquilizer. It has been mentioned by sushruta, charaka, vagbhatta as a remedy for mental illness. The oil of c. Paniculatus is used to stimulate intellect, sharpen memory and facilitate learning. It works as a powerful brain tonic. It produces improvements in iq in mentally retarded children and reduces a feeling of well-being. Clinical studies suggest that the plant exhibits neuroprotective and cognitive enhancing effects due to its antioxidative property and its capacity to modulate the cholinergic system. (International Journal of Pharma & Bio Sciences, 2012)

Draksha (Vitis Vinifera)
Common grape vine is known as draksha in ayurveda. Grape seed and skin contain several active components including flavonoids, polyphenols, anthocyanins, proanthocyanidins, procyanidines and the stilbene derivative resveratrol. It possess anti-oxidative, anti-inflammatory and antimicrobial activities as well as cardioprotective, hepatoprotective and neuroprotective effects. Grapes are sweet to taste and acts as body coolants. They are soft, heavy to digest and increase the moistness of body tissues. Due to their property of alleviating vata, the use of grapes is recommended as nervine. It boosts memory power and acts as a brain tonic. (International Journal of Science & Research, vol.6, issue 3, March 2017)

Grape derived polyphenols showed promising anti-neurodegenerative properties. Most grape polyphenols can cross the blood brain barrier in sufficient concentrations to evoke neuro-protective effects and memory enhancing potential. (Bulletin of the National Research Centre, 2019)

Shatavari (Asparagus Racemosus)
Shatavari is mentioned as medhya – the plants which increase intelligence and promote learning and memory. It is a rejuvenator herb which improves health by increasing immunity, vitality and resistance, imparting longevity as well as protection against stress. Methanolic extract of a. Racemosus show significant anti-depressant activity. Clinical studies show nootropic and anti-amnesic activities of a. Racemosus. It protects against amnesia and enhances memory. Shatavari is a well known nervine tonic in the ayurvedic system of medicine. It plays the role of an anti-oxidant and reverse the neuronal damage in neurodegenerative disorders. (International Journal of Advanced Research, 2016)

A clinical study demonstrated that a. Racemosus has significant neuroprotective activity and showed marked constructive effects for improving the learning and memory. Therefore, it can be used for the treatment of various cognitive dysfunctions connected with neurodegenerative disorders. (Journal of Alzheimer’s Disease & Parkinsonism, 2016)

Giloy (Tinospora Cordifolia)
Cordifolia is known for its large application in cure of various diseases in ayurvedic treatment. It has immunomodulatory, anti-oxidant, protective and other properties in healing certain diseases, also it can improve memory and function as a brain tonic in senile and presenile dementia. T. Cordifolia helps in improving memory and concentration and it is mentioned in ayurvedic herbal medicine. It is beneficial in treatment of adhd. Giloy is useful in brain function and stress management. The anti-stress activity was confirmed by effects on neurotransmitters. It also helps in the treatment of anxiety. (Journal of Medical Pharmaceutical & Allied Sciences, 2021)

T. cordifolia is known as medhya rasayana. Significant response has been found in children with moderate degree of behavior disorders and mental deficit, along with improvement in iq levels. In a clinical study, the pure aqueous extract of the root was found to enhance verbal learning and logical memory. It has also been shown to enhance cognition. (International Journal of Ayurveda Research, 2010)

Mulethi (Glycyrrhiza Glabra)
Mulethi is termed as medhya in classical texts of ayurveda. Mulethi is an efficient brain tonic and a revitalize for the brain. It rejuvenates the brain. In times of stress, mulethi can stimulate mental functions so as to feel a calming and relaxing effect. Mulethi increases the circulation into the central nervous system and balances the sugar levels in the blood. (Pharmacognosy Reviews, vol.2, issue 4, 2008)

Clinical studies on effects of g. Glabra extracts on learning and memory showed positive results. The combination of anti-inflammatory and antioxidant activities of g. Glabra along with neuroprotective role could lead to memory enhancing effects. G. Glabra also exhibited sedative and anxiolytic effects. Mulethi extract may have potential therapeutic value for the treatment of depressive disorders. (Phytotherapy Research, 2018)

Tulsi (Ocimum Sanctum)
Tulsi can address physical, chemical, metabolic and psychological stress through a unique combination of pharmacological actions. Tulsi can counter psychological stress through positive effects on memory and cognitive function and through its anxiolytic and antidepressant properties. Daily consumption of tulsi is said to prevent disease, promote general health, wellbeing and longevity and assist in dealing with the stresses of daily life. It is considered as a potent adaptogen. The psychotherapeutic properties of tulsi have been explored in various experiments that reveal that tulsi has anti-anxiety and anti-depressant properties. Tulsi enhances memory and cognitive function and protects against age-induced memory deficits. Tulsi has been observed to reduce stress , anxiety and depression and improves symptoms such as forgetfulness and exhaustion. Tulsi has a calming effect that leads to clarity of thought, along with a more relaxed and calm disposition. (Journal of Ayurveda & Integrative Medicine, vol. 5, issue 4 , 2014)

Ushira (Vetiveria Zizanioides)
Ushira is a tall grass characterized by a sweet and pleasant flavor that has a cooling effect. It exhibits anti-inflammtory, antiseptic, aphrodisiac, nervine, sedative, tonic and vulnerary properties. The very soothing and cooling effect of vetiver calms and pacifies all sorts of inflammations especially inflammations in circulatory and nervous system. It is a nervine tonic. It takes care of the nerves and maintains them in good health. It also heals the damages done to the nerves by shock, fear, stress etc. It helps get rid of nervous disorders, afflictions, hysteric attacks, nervous and neurotic disorders. It is a well known sedative. It sedates nervous irritations, emotional outbursts such as anger, anxiety, restlessness and even benefits patients of insomnia.  (Journal of Medicinal Plant Studies, 2013)

A clinical study on vetiver extract revealed that it possesses significant anxiolytic and nootropic activity by possibly interplaying with neurotransmitters implicated in anxiety and learning and memory. (Journal of Ayurveda & Integrative Medicine, 2015)

Dalchini (Cinnamomum Zeylanicum)
Cinnamon is one of the most important spices used daily by people all over the world. It possesses antioxidant, anti-inflammatory, antidiabetic, antimicrobial properties and also has been reported to have activities against neurological disorders. Clinical studies indicate the potential of cinnamon in the treatment of parkinson’s and alzheimer’s disease. (Evidence Based Complementary & Alternative Medicine, 2014)

Cinnamon contains phytochemicals which boost the brains ability to utilize glucose. It’s ability to improve insulin resistance also constitutes an important mechanism, whereby it limits the alzheimer induced changes in the brain as well as modulates the brain insulin signaling. Therefore, cinnamon can be used as a cognition enhancer. (Pharmacognosy Research, 2015)

Haldi (Curcuma Longa)
Turmeric is one of nature’s most powerful healers. Long known for its anti-inflammatory properties, recent research has revealed that turmeric is a natural wonder, proving beneficial in the treatment of many different health conditions from cancer to alzheimer’s disease. It has long been used in chinese medicine as a treatment for depression. The main active component of turmeric is curcumin which has anti-inflammatory and anti-oxidant properties. (Archives of Applied Science Research, 2009)

Clinical studies suggest that turmeric can substantially reduce neuroinflammation and oxidative stress and improve memory, thus making it a promising therapeutic option for prophylaxis and treatment of neurodegenerative diseases. (Bio Med Research International 2021)

Gajar (Daucus Carota)
Carrot is one of the major vegetable crops cultivated worldwide. The pharmacological studies revealed that the plant possess cytotoxic, anti-oxidant, antimicrobial, gastro-protective, hepato-protective, cardioprotective, anti-depressant, memory enhancement, anti-inflammatory effects. The effects of ethanolic extracts of d. Carots on cognitive functions and memory were studied. The results clearly indicated that d. Carota seeds is a promising therapy to improve memory especially in management of alzheimer patients. Ethanol root extract of carrot showed anti-depressant potential. The seeds contained choline, and have been reported to inhibit brain cholinesterase activity, with a possibility to elevate the brain acetylcholine levels, which is beneficial in cognitive dysfunctions. (IOSR Journal of Pharmacy, vol. 7, issue 2, Feb. 2017)

Kharbooja Seed (Cucumis Melo)
Melo seeds possess analgesic, anti-inflammatory, antioxidant, anticancer, antidiabetic, hepatoprotective effects. The seeds are a rich source of minerals, vitamins and enzyme inhibitors. Clinical studies suggest that c. Melo seeds have cognition enhancement ability. Memory enhancing effects of c. Melo may be due to the presence of cucurbitacins which produce neurogenesis and neuroprotective effects. Seeds of c. Melo contain ketogenic amines which improve cognitive functions. It implies that such properties may have a role in reducing amnesia. (Bio Med Research International , 2020)

Trikatu
Trikatu is a combination of pippali (piper longum), maricha (piper nigrum), shunthi (zingiber officinale) in equal proportion. Trikatu have miraculous pharmacological benefits for the promotion of health, preventing disease and therapeutic aspects. Trikatu has got tremendous potential to enhance the bioavailability of drugs and nutrients.

A research study proposed that after neuropharmacological screening of ethanolic extract of piper longum under acute dose founded it contains cns depressant, sedative and mild anxiolytic effect.

Methanolic extracts of piper nigrum have memory enhancing and antioxidant properties. Studies suugest that plant extract ameliorates amyloid beta induced spatial memory impairment by attenuation of oxidative stress.

Zingiber officinale can penetrate the blood brain barrier via passive diffusion. This contributes to the positive effects of ginger in the central nervous system.(World Journal of Pharmaceutical Research, 2021)

Triphala
Triphala is a well known polyherbal medicine consisting of dried fruits of emblica officianalis, terminalia bellerica, treminalia chebula. It is classified as a tridoshic rasayana in ayurvedic medicine. Triphala is used as a pillar of gastrointestinal treatment, however the complexity of three rejuvenative herbs allows for many applications. Clinical studies show stress reducing potential of triphala. It can be due to its antioxidant properties. (The Journal of Alternative & Complementary Medicine, 2017)

Clinical studies suggest that triphala might be a potential therapeutic agent to treat neurodegenerative diseases associated with oxidative stress. (Bio Med Research International , 2021)

Nishoth (Operculina Turpethum)
Turpethum is a well known medicinal herb traditionally used to treat various diseases. It is mainly used as expectorant, brain-tonic and laxative. It is also used in neurological disorders. O. Turpethum exerts anti-inflammatory, analgesic, antioxidant, anti-diabetic, antispasmodic, bronchodilator, antimicrobial and hepatoprotective actions. (Journal of Pharmacognosy & Phytochemistry, 2017)

Clinical studies show cns depressant activity of ethanolic extract of o. Turopethum suggesting it’s neuropharmacological potential. (Bio Sensors Journal, 2015)